| Identification | Back Directory | [Name]
4-MethoxycyclohexylaMine hydrochloride | [CAS]
5460-27-5 | [Synonyms]
4-methoxycyclohexanamine HCl
4-MethoxycyclohexylaMine HCl salt
4-MethoxycyclohexanaMine hydrochloride
4-MethoxycyclohexylaMine hydrochloride
4-methoxycyclohexan-1-amine,hydrochloride
Cyclohexanamine, 4-methoxy-, hydrochloride (1:1) | [EINECS(EC#)]
820-904-6 | [Molecular Formula]
C7H16ClNO | [MOL File]
5460-27-5.mol | [Molecular Weight]
165.661 |
| Questions And Answer | Back Directory | [Uses]
4-Methoxycyclohexylamine hydrochloride can be used as a pharmaceutical synthesis intermediate. | [Application]
4-Methoxycyclohexylamine hydrochloride can be used as a pharmaceutical synthesis intermediate, such as in the preparation of cis-8-methoxy-1,3-diazaspiro[4,5]dec-2,4-dione: Add 1200 mL of water to a high-pressure reactor, start stirring, add 220 g (2 mol) of 40% formamide, stir for 10 min, then add 130 g (1 mol) of 4-methoxycyclohexylamine hydrochloride, followed by 7 g of rhodium-carbon catalyst. Then, introduce C into the reactor. O, bring the pressure inside the reactor to 0.2 MPa, raise the temperature to 50°C, and keep it at that temperature for 20 hours. When the content of 1-amino-4-methoxycyclohexane in the reaction solution is less than 2%, the reaction ends. Cool down to 25-30°C, add dilute hydrochloric acid dropwise to the reaction solution, and adjust the pH to 5-6. Solid precipitates out. Filter out the product, wash the filter cake once, and obtain 155 g of dried cis-8-methoxy-1,3-diazaspiro[4,5]-dec-2,4-dione, with a yield of 78%. |
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
Heterochem
|
| Tel: |
027-88041443 13072715837 |
| Website: |
www.hetero-chem.com |
| Company Name: |
BePharm Ltd
|
| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
| Company Name: |
LEADMEDPHARM CO.,LTD
|
| Tel: |
13674959855 13674959855 |
| Website: |
http://www.synthontech.com/ |
|