| Identification | Back Directory | [Name]
6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID | [CAS]
5463-29-6 | [Synonyms]
6-bromo-2-oxo-1H-quinoline-4-carboxylic acid
6-bromo-2-keto-1H-quinoline-4-carboxylic acid
4-Quinolinecarboxylic acid, 6-bromo-1,2-dihydro-2-oxo- | [Molecular Formula]
C10H6BrNO3 | [MDL Number]
MFCD09837171 | [MOL File]
5463-29-6.mol | [Molecular Weight]
268.06 |
| Chemical Properties | Back Directory | [Boiling point ]
446.7±45.0 °C(Predicted) | [density ]
1.804±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
2.54±0.20(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
6-Bromo-2-hydroxy-4-carboxylic acid quinoline was synthesized using the method described in Scheme 6. The procedure was as follows: 5-bromoindoline-2,3-dione (0.250 g) was dissolved in tetrahydrofuran (THF, 3 ml) in a round-bottomed flask, followed by the addition of malonic acid (2 equiv). The unit was connected to a reflux condenser and heated to reflux by conventional heating and the reaction was continued overnight. After 12 hours of reaction, a solid precipitate was observed to be generated. Subsequently, the suspension was concentrated under reduced pressure to remove the solvent, and the suspension was refluxed for 4 hours after addition of an appropriate amount of water. Finally, the solid product was collected by filtration to afford 6-bromo-2-hydroxyquinoline-4-carboxylic acid (0.150 g) in solid form. | [References]
[1] Patent: US2014/221387, 2014, A1. Location in patent: Paragraph 0383; 0384; 0385 |
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