| Identification | Back Directory | [Name]
1H-Naphtho[2,3-d]triazole-4,9-dione, 1-phenyl- | [CAS]
5466-47-7 | [Synonyms]
IDO1/TDO-IN-2
1H-Naphtho[2,3-d]triazole-4,9-dione, 1-phenyl- | [Molecular Formula]
C16H9N3O2 | [MOL File]
5466-47-7.mol | [Molecular Weight]
275.26 |
| Hazard Information | Back Directory | [Uses]
IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC50s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases[1]. | [References]
[1] Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 202 DOI:10.1016/j.ejmech.2020.112703 |
|
|