| Identification | Back Directory | [Name]
O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane | [CAS]
54805-58-2 | [Synonyms]
AB-182
O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane
Carbamic acid, [[bis(2,2-dimethyl-1-aziridinyl)phosphinyl]oxy]-, ethyl ester (9CI) | [Molecular Formula]
C11H22N3O4P | [MDL Number]
MFCD01737852 | [MOL File]
54805-58-2.mol | [Molecular Weight]
291.28 |
| Hazard Information | Back Directory | [Description]
AB-182 is an aziridine derivative and antitumor agent. | [Uses]
AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups. | [References]
[1] Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979;5(9):1653-1656. DOI:10.1016/0360-3016(79)90791-0
[2] Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979;5(9):1677-1680. DOI:10.1016/0360-3016(79)90796-x |
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