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Mitonafide(54824-17-8)1HNMR
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[in vivo]

Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice[4].
Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model[6].
Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg[5].

Animal Model:S-180 bearing mice[4]
Dosage:0.5 mg/kg and 1 mg/kg
Administration:Intraperitoneal injection (i.p.) for 1-7 days
Result:Increased in median survival times.
Animal Model:HepG2 xenograft model [6]
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), twice a day.
Result:Exhibited a relative tumor increment rates (T/C) value of 28.8%.
[storage]

Store at -20°C
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