| Identification | Back Directory | [Name]
15(S)-HETE | [CAS]
54845-95-3 | [Synonyms]
C04742
AL12959
AL-12959
AL 12959
Icomucret
15(S)-HETE
(S)-15-HETE
JSFATNQSLKRBCI-VAEKSGALSA-N
15(S)-HETE MaxSpec Standard
15(S)-HETE Lipid Maps MS Standard
15(S)-HYDROXYEICOSA-5Z,8Z,11Z,13E-TETRAENOIC ACID
15(S)-HYDROXY-(5Z,8Z,11Z,13E)-EICOSATETRAENOIC ACID
(15s,5z,8z,11z,13e)-15-hydroxyeicosatetraenoic acid
(15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
(5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid
(5Z,8Z,11Z,13E,15S)-15-Hydroxy-5,8,11,13-icosatetraenoic acid
5,8,11,13-Eicosatetraenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,15S)- | [Molecular Formula]
C20H32O3 | [MDL Number]
MFCD00063590 | [MOL File]
54845-95-3.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [Boiling point ]
487.7±45.0 °C(Predicted) | [density ]
0.984±0.06 g/cm3(Predicted) | [Fp ]
14℃ | [storage temp. ]
-20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | [form ]
Liquid. | [pka]
4.75±0.10(Predicted) | [color ]
Colorless to light yellow | [BRN ]
2470466 |
| Hazard Information | Back Directory | [Description]
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis. | [Uses]
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis. | [Uses]
15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity. | [Definition]
ChEBI: An optically active form of 15-HETE having 15(S)-configuration.. | [General Description]
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ). | [Biochem/physiol Actions]
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2. | [storage]
Store at -20°C |
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