| Identification | Back Directory | [Name]
Ethanone, 1-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-, rel- | [CAS]
548472-58-8 | [Synonyms]
Ethanone, 1-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-, rel- | [Molecular Formula]
C32H34Cl2N4O4 | [MOL File]
548472-58-8.mol | [Molecular Weight]
609.54 |
| Hazard Information | Back Directory | [Description]
Nutlin-1 is a p53-MDM2 binding inhibitor, p-Glycoprotein (p-gp) transport substrate, and antitumor agent. | [Uses]
Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC50 value of 0.26 μM[1]. | [References]
[1] Lyubomir T Vassilev, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8. DOI:10.1126/science.1092472 |
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