| Identification | Back Directory | [Name]
arborinine | [CAS]
5489-57-6 | [Synonyms]
arborinine
1-Hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one
9(10H)-Acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl- | [Molecular Formula]
C16H15NO4 | [MDL Number]
MFCD00060475 | [MOL File]
5489-57-6.mol | [Molecular Weight]
285.29 |
| Chemical Properties | Back Directory | [Melting point ]
177-177.5 °C | [Boiling point ]
508.4±50.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 2 mg/mL, clear (warmed) | [form ]
powder | [pka]
7.29±0.20(Predicted) | [color ]
white to beige | [SMILES]
O=C1C2=C(C=C(C(OC)=C2O)OC)N(C)C3=C1C=CC=C3 |
| Hazard Information | Back Directory | [Uses]
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2]. | [Definition]
ChEBI: Arborinine is a member of acridines. It is functionally related to an acridone. | [in vivo]
Arborinine (40, 80 mg/kg; p.o.; for 21 days) shows antitumor activity in mouse[2]. | Animal Model: | BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)[2] | | Dosage: | 40, 80 mg/kg | | Administration: | P.o.; for 21 days | | Result: | Inhibited the growth of tumors while unchanged the body weights. |
| [IC 50]
LSD1 | [References]
[1] Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. DOI:10.29219/fnr.v66.8714
[2] Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. DOI:10.1007/s10637-020-01016-y |
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