| Identification | Back Directory | [Name]
8-Hydroxymethyl guanosine | [CAS]
54898-41-8 | [Synonyms]
8-Hydroxymethyl guanosine
Guanosine, 8-(hydroxymethyl)- | [Molecular Formula]
C11H15N5O6 | [MOL File]
54898-41-8.mol | [Molecular Weight]
313.27 |
| Hazard Information | Back Directory | [Uses]
8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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