| Identification | Back Directory | [Name]
norswertianolin | [CAS]
54954-12-0 | [Synonyms]
norswertianolin
9H-Xanthen-9-one, 8-(β-D-glucopyranosyloxy)-1,3,5-trihydroxy- | [Molecular Formula]
C19H18O11 | [MDL Number]
MFCD34568095 | [MOL File]
54954-12-0.mol | [Molecular Weight]
422.34 |
| Chemical Properties | Back Directory | [Melting point ]
265 °C (decomp) | [Boiling point ]
833.7±65.0 °C(Predicted) | [density ]
1.789±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.73±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2]. | [Definition]
ChEBI: A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and <ital Gentiana germanica. | [in vivo]
Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2].
Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2]. | Animal Model: | Male Sprague Dawley rats (10~12 weeks)[2] | | Dosage: | 4.4 mg/kg/day | | Administration: | S.c. | | Result: | Improved CSE/H2S production.
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| [References]
[1] Ren K, et al. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Res Int. 2019;2019:2692970. Published 2019 Jan 20. DOI:10.1155/2019/2692970
[2] Niu Y, et al. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021;12:677212. Published 2021 Jul 14. doi:10.3389/fphar.2021.677212 |
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