ChemicalBook--->CAS DataBase List--->54954-12-0

54954-12-0

54954-12-0 Structure

54954-12-0 Structure
IdentificationBack Directory
[Name]

norswertianolin
[CAS]

54954-12-0
[Synonyms]

norswertianolin
9H-Xanthen-9-one, 8-(β-D-glucopyranosyloxy)-1,3,5-trihydroxy-
[Molecular Formula]

C19H18O11
[MDL Number]

MFCD34568095
[MOL File]

54954-12-0.mol
[Molecular Weight]

422.34
Chemical PropertiesBack Directory
[Melting point ]

265 °C (decomp)
[Boiling point ]

833.7±65.0 °C(Predicted)
[density ]

1.789±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

6.73±0.20(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2].
[Definition]

ChEBI: A beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and <ital Gentiana germanica.
[in vivo]

Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2].
Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2].

Animal Model:Male Sprague Dawley rats (10~12 weeks)[2]
Dosage:4.4 mg/kg/day
Administration:S.c.
Result:Improved CSE/H2S production.
[References]

[1] Ren K, et al. Effects of Four Compounds from Gentianella acuta (Michx.) Hulten on Hydrogen Peroxide-Induced Injury in H9c2 Cells. Biomed Res Int. 2019;2019:2692970. Published 2019 Jan 20. DOI:10.1155/2019/2692970
[2] Niu Y, et al. Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension. Front Pharmacol. 2021;12:677212. Published 2021 Jul 14. doi:10.3389/fphar.2021.677212
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