| Identification | Back Directory | [Name]
hydrocotarnine | [CAS]
550-10-7 | [Synonyms]
Hydrocotarnine Hydrochloride
Noscapine Impurity 3(Hydrocotarnine)
4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline
4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline
5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline
8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-
1,2,3,4-Tetrahydro-2-methyl-6,7-(methylenebisoxy)-8-methoxyisoquinoline
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline hydrate hydrochloride | [EINECS(EC#)]
208-978-2 | [Molecular Formula]
C12H15NO3 | [MDL Number]
MFCD00868501 | [MOL File]
550-10-7.mol | [Molecular Weight]
221.25 |
| Chemical Properties | Back Directory | [Melting point ]
56°C | [Boiling point ]
362.31°C (rough estimate) | [density ]
1.1514 (rough estimate) | [refractive index ]
1.5200 (estimate) | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
7.75±0.20(Predicted) | [color ]
Light Brown to Orange |
| Hazard Information | Back Directory | [Uses]
Hydrocotarnine Hydrochloride, is an oxidative degradation product of the drug Noscapine (128-62-1). | [Definition]
ChEBI: 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline is a member of isoquinolines. | [in vivo]
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) shows inhibitory effect on Cbl and results in increasing IL-18 levels, indicating that NLRP3 inflammasome activation is enhanced in mice[1].
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) protects mice from DSS-induced colitis, with low scores of pathological evaluation of inflammation, epithelial defects, and crypt atrophy[1]. | Animal Model: | DSS-induced colitis model in C57BL/6 mice (6-9 weeks old)[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; once daily; 9 days while 2.5% DSS treatment began on day 1 and ended on day 7 | | Result: | Significantly attenuated the weight loss of DSS-induced colitis mice compared to PBS-treated control mice, indicating that decreasing negative regulation of the NLRP3 inflammasome activation could attenuate colitis in an animal model.
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