| Identification | Back Directory | [Name]
6-METHYLPYRAZINE-2-CARBOXYLIC ACID | [CAS]
5521-61-9 | [Synonyms]
Glipizide Impurity 8
Glipizide Impurity 13
Glipizide Impurity 35
6-methylpyrazinoic acid
2-Carboxy-6-methylpyrazine
2-Methylpyrazine-6-carboxylic acid
6-methyl-2-Pyrazinecarboxylic acid
6-METHYLPYRAZINE-2-CARBOXYLIC ACID
2-Pyrazinecarboxylic acid, 6-methyl-
6-Methylpyrazine-2-carboxylic acid 97% | [Molecular Formula]
C6H6N2O2 | [MDL Number]
MFCD08705756 | [MOL File]
5521-61-9.mol | [Molecular Weight]
138.124 |
| Chemical Properties | Back Directory | [Melting point ]
138-140℃ | [Boiling point ]
302.8±37.0 °C(Predicted) | [density ]
1.319 | [storage temp. ]
Sealed in dry,2-8°C | [pka]
3.10±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
6-Methylpyrazinecarboxylic Acid can be used to synthesize compounds that are active against M.tuberculosis H37Rv. Similarly, it can be used to synthesize compounds that are useful for the inhibition, prevention or therapy of tumor cell invasion, metastasis, inflammation, hepatitis, or liver dysfunction. | [Synthesis]
2,6-Dimethylpyrazine (500mg, 4.60mmol) was dissolved in water (10ml), heated at 700C and KMnO4 in water (25ml) was added dropwise. The mixture was stirred and heated overnight. After cooling to room temperature the MnO2 cake was filtered and washed with water several times. The filtrate was acidified with 5M HCI solution (pH 1.5) and extracted with ethyl acetate (3 x 50ml). The residue was dried over magnesium sulphate, filtered and evaporated to afford the product (D25); MS (ES+) m/e 139 [M+H]+. |
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