| Identification | Back Directory | [Name]
Resolvin E1 | [CAS]
552830-51-0 | [Synonyms]
RvE1
Resolvin E1
Resolvin E1,Resolvin E-1
Eicosapentaenoic Acid Impurity 15
Resolvin E1
DISCONTINUED, offer R144690
6,8,10,14,16-Eicosapentaenoic acid, 5,12,18-trihydroxy-, (5S,6Z,8E,10E,12R,14Z,16E,18R)- | [Molecular Formula]
C20H30O5 | [MDL Number]
MFCD30720094 | [MOL File]
552830-51-0.mol | [Molecular Weight]
350.449 |
| Chemical Properties | Back Directory | [Boiling point ]
591.3±50.0 °C(Predicted) | [density ]
1.112±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -80°C, protect from light | [solubility ]
DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .05 mg/ml | [form ]
Liquid | [pka]
4.66±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Resolvin E1 is an omega-3 polyunsaturated fatty acid derivative that exhibits potent anti-inflammatory, pro-resolution, and anti-nociceptive effects. Resolvin E1 has been shown to inhibit neuropathic pain and spinal cord microgial activation following peripheral nerve injury. | [Definition]
ChEBI: Resolvin E1 is a resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer). It has a role as an anti-inflammatory agent and a human xenobiotic metabolite. It is a nonclassic icosanoid, a long-chain fatty acid, a resolvin, a triol and a hydroxy polyunsaturated fatty acid. It is a conjugate acid of a resolvin E1(1-). | [in vivo]
Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS (2,4,6-trinitrobenzene sulfonic acid) colitis[1]. | Animal Model: | 6- to 8-week-old female BALB/c mice (TNBS colitis model)[1] | | Dosage: | 1.0 μg per mouse; 50 μg/kg | | Administration: | i.p.; on days -8, -1, and 0 before the induction of colitis | | Result: | Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively. |
| [IC 50]
Human Endogenous Metabolite |
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Energy Chemical
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http://www.energy-chemical.com |
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