| Identification | Back Directory | [Name]
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE | [CAS]
55314-49-3 | [Synonyms]
u47473
13e,15s)-1-alph
pgf2-alpha1,15-lactone
Prostaglandin F2α 1,15-lactone
PROSTAGLANDIN F2ALPHA 1,15-LACTONE
prosta-5,13-dien-1-oicacid,9,11,15-trihydroxy-,lambda-lactone,(5z,9-alpha,1
9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, 1,15-LACTONE
(1R,3Z,10S,11E,13R,14R,16S)-14,16-dihydroxy-10-pentyl-9-oxabicyclo[11.3.0]hexadeca-3,11-dien-8-one | [Molecular Formula]
C20H32O4 | [MDL Number]
MFCD00065774 | [MOL File]
55314-49-3.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >20.4 mg/ml; DMSO: >10 mg/ml; Ethanol: >105 mg/ml; Ethanol:PBS (30:70): 8 mg/ml; PBS (pH 7.2): <50 ug/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective. | [Uses]
PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey[1]. | [in vivo]
PGF2α 1,15-lactone (5 mg for i.v.; 3 mg for intramuscularly) terminates early pregnancy in the monkey[1]. | Animal Model: | Rhesus monkey (trimester pregnant)[1] | | Dosage: | 5 mg for i.v.; 3 mg for intramuscularly | | Administration: | IV on days 30 and 31, 31 and 32, or 33 and 34; Intramuscularly on days 29 and 30, 30 and 31, or 33 and 34 | | Result: | Aborted between 36 and 48 hr after treatment, Within 10 minutes after treatment there was a significant increase in uterine tone and frequency of contractions. |
| [storage]
Store at -20°C | [References]
[1] Spilman CH, et al. Effects of PGF2alpha and PGF2alpha, 1-15 lactone on the corpus luteum and on early pregnancy in the rhesus monkey. Prostaglandins. 1977 Sep;14(3):477-88. DOI:10.1016/0090-6980(77)90262-3 |
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