| Identification | Back Directory | [Name]
1-Hydroxy-8-methoxyanthraquinone | [CAS]
5539-66-2 | [Synonyms]
1-Hydroxy-8-methoxyanthraquinone
1-Methoxy-8-hydroxy-9,10-anthraquinone
1-Hydroxy-8-methoxy-9,10-anthraquinone
1-Hydroxy-8-methoxyanthracene-9,10-dione
9,10-Anthracenedione, 1-hydroxy-8-methoxy- | [Molecular Formula]
C15H10O4 | [MDL Number]
MFCD00666925 | [MOL File]
5539-66-2.mol | [Molecular Weight]
254.24 |
| Chemical Properties | Back Directory | [Melting point ]
196.8-198 °C | [Boiling point ]
480.5±45.0 °C(Predicted) | [density ]
1.400±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Solid | [pka]
6.75±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
6PGD-IN-1 (compound S3) is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD). IC50 and Kd the value of 17.8μM and 17.1 μM respectively. 6PGD-IN-1 has antitumor activity[1]. | [in vivo]
6PGD-IN-1 (20 mg/kg/day intraperitoneally for 4 weeks) reduces tumor growth and volume in xenografted nude mice injected subcutaneously with H1299 cells[1].
| Animal Model: | H1299-xenograft mice[1] | | Dosage: | 20 mg/kg | | Administration: | i.p. | | Result: | Decreased 6PGD activity and reduced Ki-67 expression. |
| [References]
[1] Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. DOI:10.1038/ncb3255 |
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