| Identification | Back Directory | [Name]
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE | [CAS]
55400-73-2 | [Synonyms]
MS-PEG4-MS
Ms-PEG5-Ms
1,11-BIS(METHANESULFONYLOXY)-3,6,9-TRIOXANDECANE
3,6,9,12-Tetraoxa-13-thiatetradecan-1-ol 1-Methanesulfonate 13,13-Dioxide | [Molecular Formula]
C10H22O9S2 | [MDL Number]
MFCD04039441 | [MOL File]
55400-73-2.mol | [Molecular Weight]
350.406 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Oil | [Boiling point ]
533.6±45.0 °C(Predicted) | [density ]
1.310±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, Refrigerator, Under Inert Atmosphere | [solubility ]
Dichloromethane | [form ]
Oil | [color ]
Colorless | [CAS DataBase Reference]
55400-73-2 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Oil | [Description]
Ms-PEG5-Ms are PEG linkers containing two mesyl moieties. The mesyl groups are good leaving groups and can also be used as protecting groups for primary alcohols. They can be deprotected in the presence of sodium amalgam. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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