| Identification | Back Directory | [Name]
1H-[1]Benzopyrano[4,3-d][1]benzoxepin-4,11-diol, 7,8-dihydro-1-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (1R)- | [CAS]
554431-74-2 | [Synonyms]
JNJ17148066
JNJ-17148066
JNJ 17148066
1H-[1]Benzopyrano[4,3-d][1]benzoxepin-4,11-diol, 7,8-dihydro-1-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (1R)- | [Molecular Formula]
C30H31NO5 | [MOL File]
554431-74-2.mol | [Molecular Weight]
485.58 |
| Hazard Information | Back Directory | [Description]
JNJ-17148066 is an estrogen receptor ESR1 agonist. | [Uses]
Estrogen receptor modulator 12 (compound 1a-(R)) is a selective estrogen receptor modulator with estrogen agonist and antagonist activities in in vivo models. Estrogen receptor modulator 12 exhibits antagonist effects on the uterus and estrogen agonist activities on bone, plasma lipids, hot flashes, and vagina in in vivo models, and is a potential compound for suppressing postmenopausal symptoms. | [References]
[1] Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms |
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