| Identification | Back Directory | [Name]
ANISODAMINE HYDROBROMIDE | [CAS]
55449-49-5 | [Synonyms]
ANISODAMINE HYDROBROMIDE
ANISODAMINE HYDROBROMIDE USP/EP/BP | [Molecular Formula]
C7H10BrNO | [MDL Number]
MFCD01941199 | [MOL File]
55449-49-5.mol | [Molecular Weight]
204.064 |
| Hazard Information | Back Directory | [Uses]
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2]. | [in vivo]
Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%[2]. | Animal Model: | LPS-Induced Shock Mice[2] | | Dosage: | 50 mg/kg | | Administration: | I.p. | | Result: | Markedly decreased the mortality to 20%.
|
| [References]
[1] Eisenkraft A. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016;173(11):1719-1727. DOI:10.1111/bph.13486
[2] Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641. DOI:10.1097/CCM.0b013e31819598f5 |
|
| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
|