| Identification | Back Directory | [Name]
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine | [CAS]
55476-47-6 | [Synonyms]
PSB-12062
PSB-12062 >=98% (HPLC)
10-Tosyl-10H-phenoxazine
N-(p-Methylphenylsulfonyl)phenoxazine
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]- | [Molecular Formula]
C19H15NO3S | [MDL Number]
MFCD01646529 | [MOL File]
55476-47-6.mol | [Molecular Weight]
337.39 |
| Hazard Information | Back Directory | [Uses]
PSB-12062 has been used as a P2X4 antagonist to pre-tre at macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-tre at P2X7-deficient BV-2 cells to elucidate the roles of P2X4. | [Biological Activity]
PSB-12062 is a potent and selective P2X4 antagonist with IC50 value of 1.38 μM for human P2X4. | [in vitro]
10-Tosyl-10H-phenoxazine shows similar potency in human, rat, and mouse species.It shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However,it is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM). | [target]
IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4) |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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