| Identification | Back Directory | [Name]
TRIS-(2-CHLOROETHYL)-AMINE | [CAS]
555-77-1 | [Synonyms]
hn3
HsN3
ts160
tl145
TL 145
A 8729
TS 160
PROS26
agenthn3
ai3-16198
NSC-260424
Sinalost base
Nitrogen Lost
Trimitan base
AURORA KA-7833
Trichlormethine
NITROGENMUSTARD-3
Tri-2-chloroethylamine
Tris(b-chloroethyl)amine
tri-(2-chloroethyl)amine
TRIS-(2-CHLOROETHYL)-AMINE
2,2',2''-Trichloroetylamine
Tris(beta-chloroethyl)amine
2,2',2-Trichlorotriethylamine
2,2’,2"-trichloro-triethylamin
2,2’,2"-trichlorotriethylamine
2,2’,2’’-trichloro-triethylamin
2,2’,2’’-trichlorotriethylamine
2,2',2''-Trichlorotriethylamine
Triethylamine, 2,2',2''-trichloro-
2-chloro-n,n-bis(2-chloroethyl)-ethanamin
2-Chloro-N,N-bis(2-chloroethyl)ethanamine
Ethanamine, 2-chloro-N,N-bis(2-chloroethyl)- | [Molecular Formula]
C6H12Cl3N | [MDL Number]
MFCD00045288 | [MOL File]
555-77-1.mol | [Molecular Weight]
204.53 |
| Chemical Properties | Back Directory | [Description]
Nitrogen mustards are very potential chemical substances of yesteryears and produced during the 1920s and 1930s as chemical warfare weapons. They are vesicants (or blister agents) similar to the sulphur mustards. They smell fishy, musty, soapy, or fruity and are either in the form of an oily textured liquid or a vapour (the gaseous form of a liquid) or a solid. It is in liquid form at normal room temperature (70 F) with a clear, pale amber, or yellow colour. HN-1, HN-2, and HN-3 are the military designations of nitrogen mustard (for more data, refer to Muatars gas). Nitrogen mustards (HN-1, HN-2, HN-3) are colourless to yellow, oily liquids that evaporate very slowly. HN-1 has a faint fishy or musty odour. HN-2 has a soapy odour at low concentrations and a fruity odour at higher concentrations. HN-3 may smell like butter almond. Use of nitrogen mustards is very much restricted other than for chemical warfare. In fact, presently, its use has no records. HN-1 has been used to remove warts in the past, and HN-2 has been used sparingly in chemotherapy. | [Appearance]
HN-3, a nitrogen mustard blister agent (vesicants,
is a colorless to pale yellow liquid. Pure material is
odorless; otherwise, it has a faint fish-or soap-like odor. | [Melting point ]
-4° | [Boiling point ]
bp15 144° | [density ]
d425 1.2347 | [refractive index ]
nD25 1.4925 | [storage temp. ]
-20°C |
| Hazard Information | Back Directory | [General Description]
Liquid with faint odor of fish and soap, no odor when pure. Used as a delayed-action casualty military agent. | [Air & Water Reactions]
Acts as a strong base in water. | [Reactivity Profile]
When dissolved in water, TRIS-(2-CHLOROETHYL)-AMINE is a strong base; reacts violently with strong oxidants and acids ; attacks copper and copper compounds. [Handling Chemicals Safely 1980. p. 123]; reacts with hypochlorites to give N-chloroamines, some of which are explosives when isolated [Bretherick 1979. p. 108]. | [Health Hazard]
Most toxic of the nitrogen mustards. The median lethal dose for inhalation is 1,500 mg-min/m3; for skin absorption (masked personnel) is 10,000 mg-min/m3. The medium incapacitating dose for eye injury is 200 mg-min/m3; for skin absorption is 2,500 mg-min/m3. | [Fire Hazard]
When heated to decomposition, TRIS-(2-CHLOROETHYL)-AMINE emits chloride and nitrogen oxides. No action on metals or other materials if material is kept dry. Avoid decomposing heat. | [Potential Exposure]
Trichlorotriethylamine is a (slowacting)
vesicant but has never been used in military conflict.
Is used as an antineoplastic agent. Has been tested as
a fixing agent in textile dyes. | [First aid]
There is no antidote for nitrogen mustard toxicity.
Because health effects due to nitrogen mustard may not
occur until several hours after exposure, patients/victims
should be observed in a hospital setting for at least
24 hours. Gastric lavage is contraindicated following ingestion
of this agent due to the risk of perforation of the
esophagus or upper airway. If this chemical gets into the
eyes, remove any contact lenses at once and irrigate immediately
for at least 15 minutes, occasionally lifting upper
and lower lids. Seek medical attention immediately. If this
chemical contacts the skin, remove contaminated clothing
and wash immediately with soap and water. Speed in
removing material from skin is of extreme importance.
Seek medical attention immediately. If this chemical has
been inhaled, remove from exposure, begin rescue breathing
(using universal precautions, including resuscitation
mask) if breathing has stopped and CPR if heart action has
stopped. Transfer promptly to a medical facility. When this
chemical has been swallowed, get medical attention. Give
large quantities of water and induce vomiting. Do not make
an unconscious person vomit. Keep victim quiet and maintain
normal body temperature. Effects may be delayed;
keep victim under observation. | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. Military driver of HN-3 shall be given full
and complete information regarding shipment and conditions
in case of emergency. AR 50-6 deals specifically with
the shipment of chemical agents. Shipments of agent will
be escorted in accordance with AR 740-32. | [Incompatibilities]
HN-3 is not stable; it undergoes slow but
steady polymerization. Avoid contamination with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, bleaches and pool chemicalsetc);
contact may cause fires or explosions. Keep away from alkaline
materials, strong bases, strong acids, oxoacids, epoxides.
Unstable in the presence of light and heat and forms dimers
at temperatures above 50℃. HN-3 decomposes before its
boiling point is reached or condenses under all conditions;
the reactions involved could generate enough heat to cause
an explosion. Polymerizes slowly, so munitions would be
effective for several years. Heated to decomposition emits
hydrogen chloride and nitrogen oxide. Note: Chlorinating
agents destroy nitrogen mustards. Dry chlorinated lime and
chloramines with a high content of active chlorine vigorously
chlorinate nitrogen mustards to the carbon chain giving
low toxicity products. In the presence of water this interaction
proceeds less actively. They are rapidly oxidized by peracids
in aqueous solution at weakly alkaline pH. In acid
solution the oxidation is much slower. |
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