| Identification | Back Directory | [Name]
schisandronic acid | [CAS]
55511-14-3 | [Synonyms]
Ganwuweizic acid
schisandronic acid
Schizandronic acid
9,19-Cyclolanost-24-en-26-oic acid, 3-oxo-, (24Z)-
(24Z)-3-Oxo-9,19-cyclo-5α-lanost-24-en-26-oic acid
(24Z)-3-Oxo-9,19-cyclo-5α-lanosta-24-ene-26-oic acid | [Molecular Formula]
C30H46O3 | [MOL File]
55511-14-3.mol | [Molecular Weight]
454.68 |
| Hazard Information | Back Directory | [Description]
Schisandronic acid is a triterpenoid acid isolated from the stems of Schisandra propinqua. | [Uses]
Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects[1]. | [References]
[1] Cytotoxicity of Schisandronic Acid from Kadsura coccinea by Activation of Caspase-3, Cleavage of poly-ADP Ribose Polymerase, and Reduction of Oxidative Stress |
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