| Identification | Back Directory | [Name]
(R)-(+)-AMINOGLUTETHIMIDE 97 | [CAS]
55511-44-9 | [Synonyms]
CGS-2396
Aminoglutethimide, D-
(R)-(+)-Aminoglutethimide 97%
(R)-(+)-AMINOGLUTETHIMIDE 97
(R)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
(R)-3-(4-aMinophenyl)-3-ethylpiperidine-2,6-dione
(3R)-3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-, (3R)- | [Molecular Formula]
C13H16N2O2 | [MDL Number]
MFCD03094025 | [MOL File]
55511-44-9.mol | [Molecular Weight]
232.28 |
| Chemical Properties | Back Directory | [Melting point ]
115.5-119.5 °C (lit.) | [Boiling point ]
457.4±45.0 °C(Predicted) | [density ]
1.173±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Solid | [pka]
11.60±0.40(Predicted) | [color ]
Off-white to light yellow | [Optical Rotation]
[α]20/D +160°, c = 1 in methanol | [InChI]
1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)/t13-/m1/s1 | [InChIKey]
ROBVIMPUHSLWNV-CYBMUJFWSA-N | [SMILES]
CC[C@@]1(CCC(=O)NC1=O)c2ccc(N)cc2 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
(R)-(+)-Aminoglutethimide can be used:
- As a building block for the development of cephalosporin based prodrug for antibody-directed enzyme prodrug therapy (ADEPT).
- To prepare (R)-3-ethyl-3-(4-(3,4,5-trimethoxybenzylamino)phenyl)piperidine-2,6-dione by reacting with 3,4,5-trimethoxybenzylamine via deaminative coupling reaction.
- To synthesize (R)-2-fluoro-2-(4-methoxyphenyl)-N-(R)-(+)-aminoglutethimide by enantioselective α-fluorination.
| [Definition]
ChEBI: The (3R)-enantiomer of aminoglutethimide. | [in vivo]
(R)-(+)-Aminoglutethimide (5, 50 mg/kg; p.o.) eliminates within 48 hr into urine and feces, mostly in the form of metabolites[2].
(R)-(+)-Aminoglutethimide (1, 10, 50 mg/kg; i.p.; 60 min before training) dose not induce any significant effect in 1 and 10 mg/kg, induces a loss of retention at 50 mg/kg in day-old chicks[3]. | [IC 50]
Aromatase |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|