| Identification | Back Directory | [Name]
5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8,11-dihydroxy-7-methoxy-, (2E,11R,11aS)- | [CAS]
55511-85-8 | [Synonyms]
11-Demethyltomaymycin
5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8,11-dihydroxy-7-methoxy-, (2E,11R,11aS)- | [Molecular Formula]
C15H18N2O4 | [MOL File]
55511-85-8.mol | [Molecular Weight]
290.31 |
| Hazard Information | Back Directory | [Uses]
11-Demethyltomaymycin is an antibiotic. 11-Demethyltomaymycin has antiviral activity against Escherichia coli T1 and T3 phages and antibacterial activity against Gram-positive bacteria. In addition, 11-Demethyltomaymycin is cytotoxic to leukemia L1210 cells[1][2]. | [References]
[1] Hurley LH, et al. Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes. Biochemistry. 1976 Aug 24;15(17):3760-9. DOI:10.1021/bi00662a019
[2] Hurley L H, et al. Biosynthesis of the antiviral antibiotic 11-demethyltomaymycin by Streptomyces achromogenes. Journal of the Chemical Society, Chemical Communications, 1975 (4): 120-121. |
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