| Identification | Back Directory | [Name]
HU-580 | [CAS]
55658-71-4 | [Synonyms]
HU-580
Cannabidiolinsaeure-methylester
Cannabidiolic Acid methyl ester
Benzoic acid, 2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-6-pentyl-, methyl ester | [Molecular Formula]
C23H32O4 | [MOL File]
55658-71-4.mol | [Molecular Weight]
372.5 |
| Chemical Properties | Back Directory | [Boiling point ]
537.6±50.0 °C(Predicted) | [density ]
1.081±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml | [pka]
8.35±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects[1][2][3]. | [IC 50]
5-HT1A Receptor | [References]
[1] Pertwee RG, et al. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol. 2018 Jan;175(1):100-112. DOI:10.1111/bph.14073
[2] Zhu YF, et al. An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. Br J Pharmacol. 2020 Jun;177(12):2712-2725. DOI:10.1111/bph.14997
[3] Murillo-Rodríguez E, et al.Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats. J Cannabis Res. 2021 Jul 12;3(1):31. DOI:10.1186/s42238-021-00081-1 |
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