| Identification | Back Directory | [Name]
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl 8'-β-D-glucopyranosyl ester | [CAS]
55750-86-2 | [Synonyms]
Crocin-4
Crocin Impurity 5
8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl 8'-β-D-glucopyranosyl ester
β-D-Glucopyranose, 1-[methyl (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] | [Molecular Formula]
C27H36O9 | [MOL File]
55750-86-2.mol | [Molecular Weight]
504.57 |
| Hazard Information | Back Directory | [Uses]
Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities[1][2][3]. | [in vivo]
Crocin-4 (50 mg/kg; i.p.) is capable of crossing the Blood Brain Barrier (BBB) and build up levels in the mouse brain[3].
| [References]
[1] Chalatsa I, et, al. The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models. Front Neurosci. 2019 Mar 26;13:249. DOI:10.3389/fnins.2019.00249
[2] Koulakiotis NS, et, al. Crocus-derived compounds alter the aggregation pathway of Alzheimer's Disease: associated beta amyloid protein. Sci Rep. 2020 Oct 23;10(1):18150. DOI:10.1038/s41598-020-74770-x
[3] Karkoula E, et, al. Trans-crocin 4 is not hydrolyzed to crocetin following i.p. administration in mice, while it shows penetration through the blood brain barrier. Fitoterapia. 2018 Sep;129:62-72. DOI:10.1016/j.fitote.2018.06.012 |
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