| Identification | Back Directory | [Name]
iopydol | [CAS]
5579-92-0 | [Synonyms]
Iopidol
iopydol
Iopidolo
Iopydolum
Jopydolum
EINECS 226-968-6
1-glyceryl-3,5-diiodo-4-pyridone
1-(2,3-dihydroxypropyl)-3,5-diiodopyridin-4-one
1-(2,3-dihydroxypropyl)-3,5-diiodo-pyridin-4-one
1-(2,3-Dihydroxypropyl)-3,5-diiodo-4(1H)-pyridone
1-(2,3-Dihydroxypropyl)-3,5-diiodo-4(1H)-pyridinone
1-(2,3-dihydroxy-propyl)-3,5-diiodo-1H-pyridin-4-one
4(1H)-Pyridinone, 1-(2,3-dihydroxypropyl)-3,5-diiodo- | [EINECS(EC#)]
226-968-6 | [Molecular Formula]
C8H9I2NO3 | [MDL Number]
MFCD00867925 | [MOL File]
5579-92-0.mol | [Molecular Weight]
420.97 |
| Hazard Information | Back Directory | [Originator]
Hytrast Vial,Guerbet | [Uses]
Diagnostic aid (radiopaque medium, bronchographic)
. | [Uses]
Iopydol is the X-ray contrast reagent. | [Definition]
ChEBI: Iopydol is a chloropyridine. | [Manufacturing Process]
50 g 4-pyridone was dissolved in 300 ml 20% hydrochloric acid and slowly
mixed with 180 g of chloroiodide in 200 ml 20% hydrochloric acid. Then the
obtained dark solution was strong alkalized with sodium hydroxide. The
solvent was removed to dryness and sodium salt diiod-4-pyridone was
obtained. It was dissolved in water, filtered and equivalent quantity of glacial
acetic acid or hydrochloric acid was added to give 3,5-diiod-4-pyridone as a
powder. 34.5 g 3,5-diiod-pyridone was dissolved in 100 ml 1 N NaOH by
heating on a water bath and added to a 15 g of monochlorohydrine added.
The mixture was heated on water bath before a dense pasty mass obtained. It
was filtered off and treated with 1 N NaOH. The obtained 1-(2,3-
dihydroxypropyl)-3,5-diiodo-4(1H)-pyridinone was recrystallized from diluted
hydrochloric acid. MP: 161°C. | [Therapeutic Function]
Diagnostic aid |
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