| Identification | Back Directory | [Name]
3'-O-Methyltaxifolin | [CAS]
55812-91-4 | [Synonyms]
Dihydroisorhamnetin
3'-O-Methyltaxifolin
4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-, (2R,3R)- | [Molecular Formula]
C16H14O7 | [MOL File]
55812-91-4.mol | [Molecular Weight]
318.28 |
| Hazard Information | Back Directory | [Uses]
3'-O-Methyltaxifolin ((+)-Dihydroisorhamnetin) is a dihydroflavanol found in Pulicaria jaubertii. A mixture of these alcohol compounds including 3'-O-Methyltaxifolin found in Pulicaria jaubertii exhibits antitumor activity with IC50 values ??of 19.1 μg, 20.0 μg, and 24.1 μg against prostate cancer (PC-3), breast cancer (MCF-7), and hepatocellular carcinoma (HepG-2) cell lines, respectively. Furthermore, 3'-O-Methyltaxifolin can induce cell apoptosis, making it a promising candidate for anticancer research.[1]. | [Definition]
ChEBI: (+)-dihydroisorhamnetin is a dihydroisorhamnetin that has 2R,3R-configuration. It has a role as a plant metabolite. | [References]
[1] Ragab EA, et al. A new monoterpene glucoside and complete assignments of dihydroflavonols of Pulicaria jaubertii: potential cytotoxic and blood pressure lowering activity. Nat Prod Res. 2016 Jun;30(11):1280-8. DOI:10.1080/14786419.2015.1055492
[2] Mohammed HA, et al. Comparative Anticancer Potentials of Taxifolin and Quercetin Methylated Derivatives against HCT-116 Cell Lines: Effects of O-Methylation on Taxifolin and Quercetin as Preliminary Natural Leads. ACS Omega. 2022 Dec 7;7(50):46629-46639. DOI:10.1021/acsomega.2c05565 |
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