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558447-26-0

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558447-26-0 Structure

558447-26-0 Structure
IdentificationBack Directory
[Name]

AMD 070
[CAS]

558447-26-0
[Synonyms]

AMD 070
AMD-11070
Mavorixafor
AMD070/AMD-070
Mavorixafor(AMD-070)
N-(1H-benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)
AMD 070 N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]- (9CI)
N'-(1H-Benzimidazol-2-ylmethyl)-N'-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
1,4-ButanediaMine, N-(1H-benziMidazol-2-ylMethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-
N'-(1h-benzimidazol-2-ylmethyl)-n'-[(8s)-5,6,7,8-tetrahydroquinolin-8-yl]butane-1,4-diamine
1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-
(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diami
(S)-N1-((1H-benzo[d]iMidazol-2-yl)Methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diaMine
Mavorixafor,CXCR,AMD 070,Human immunodeficiency virus,AMD070,HIV,inhibit,CXC chemokine receptors,Inhibitor
[Molecular Formula]

C21H27N5
[MDL Number]

MFCD11977316
[MOL File]

558447-26-0.mol
[Molecular Weight]

349.47
Chemical PropertiesBack Directory
[Melting point ]

108-110℃
[Boiling point ]

597.0±50.0 °C(Predicted)
[density ]

1.21
[storage temp. ]

Store at -20°C
[solubility ]

≥17.45 mg/mL in DMSO; ≥44.5 mg/mL in EtOH; ≥7.47 mg/mL in H2O with gentle warming
[form ]

oil
[pka]

11.65±0.10(Predicted)
[color ]

brown
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

N-(1H-Benzimidazol-2-ylmethyl)-N-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine is a potent CXCR4 inhibitor that inhibits X4 HIV-1 replication and the gp120/CXCR4 interaction. It also has therapeutic potential for developing treatments for B-RAF wild-type and mutated melanomas.
[Definition]

ChEBI: AMD 070 is an aminoquinoline.
[in vivo]

Mavorixafor (AMD-070) (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss[2].

[IC 50]

125I-SDF-CXCR4: 13 nM (IC50); HIV-1 (NL4.3 strain): 1 nM (IC50, in MT-4 cells); HIV-1 (NL4.3 strain): 9 nM (IC50, in PBMCs); HIV-1 (NL4.3 strain): 3 nM (IC90, in MT-4 cells); HIV-1 (NL4.3 strain): 26 nM (IC90, in PBMCs)
Spectrum DetailBack Directory
[Spectrum Detail]

AMD 070(558447-26-0)1HNMR
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