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558480-40-3

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558480-40-3 Structure

558480-40-3 Structure
IdentificationBack Directory
[Name]

Volociximab
[CAS]

558480-40-3
[Synonyms]

Volociximab
Research Grade Volociximab (DHC35101)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Antiangiogenic agent to treat solid tumors and age-related macular degeneration.
[in vivo]

Volociximab (300 μg/eye; intravitreal injection; once weekly for 4 weeks) has well tolerance and inhibits angiogenesis in laser induced choroidal neovascularization (CNV) of cynomolgus monkey model[1].
Volociximab (10 mg/kg; i.v.; twice weekly for 3 weeks) suppresses tumor progress in rabbits VX2 model[2].

[IC 50]

α5β1: 0.2 nM (EC50)
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