| Identification | Back Directory | [Name]
4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- | [CAS]
560103-80-2 | [Synonyms]
N-[4-(2,4-Dimethylphenyl)thiazol-2-yl]isonicotinamide
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide
4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- | [Molecular Formula]
C17H15N3OS | [MDL Number]
MFCD03384899 | [MOL File]
560103-80-2.mol | [Molecular Weight]
309.385 |
| Chemical Properties | Back Directory | [Melting point ]
150 °C | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble | [form ]
powder to crystal | [pka]
5.40±0.70(Predicted) | [color ]
White to Light yellow to Light orange |
| Hazard Information | Back Directory | [Uses]
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity. It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s=1.1, 3.4, 1.6, and 1.2 μM, respectively). | [storage]
-20°C | [References]
[1] Qiu, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J. Med. Chem. 52(6), 1757-1767 (2009). |
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