| Identification | Back Directory | [Name]
IONOMYCIN CALCIUM SALT | [CAS]
56092-82-1 | [Synonyms]
ATCC 31005
Ionomycin,Ion
IONOMYCIN (CA)
SQ23377 calcium
IONOMYCIN CA-SALT
ionomycin calcium
Calcium ionomycin.
Ionomycin Ca2+ salt
IONOMYCIN CALCIUM SALT
IONOMYCIN CALCIUM SALT 1MG
Ionomycin Ca2+ Salt
IONOMYCIN CALCIUM (SQ23377 CALCIUM)
IONOMYCIN, CALCIUM SALT, STREPTOMYCES CONGLOBATUS
Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacidcalciumsalt
10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-(2S,2R,5S,5S)-octahydro-5-(1R)-1-hydroxyethyl-2,5-dimethyl2,2-bifuran-5-yl-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)- | [EINECS(EC#)]
617-954-4 | [Molecular Formula]
C41H70CaO9 | [MDL Number]
MFCD00083634 | [MOL File]
56092-82-1.mol | [Molecular Weight]
747.07 |
| Chemical Properties | Back Directory | [Melting point ]
205-206 C | [Fp ]
87 °C | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol | [form ]
White to off-white solid | [color ]
white to off-white | [biological source]
Streptomyces conglobatus | [Sensitive ]
Light Sensitive | [BRN ]
1416163 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro. | [Chemical Properties]
Powder | [Uses]
Ionomycin is more effectivethan A23187 as a Ca++ionophore;
Ionomycin is used in research on Ca++ transport across biological membranes;
Ionomycin induces apoptotic degeneration of embryonic cortical neurons. | [General Description]
Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953). | [Biological Activity]
Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ). | [Biochem/physiol Actions]
Product does not compete with ATP. | [storage]
-20°C | [References]
Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815
Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892 |
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