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5612-61-3

5612-61-3 Structure

5612-61-3 Structure
IdentificationBack Directory
[Name]

1-(DIMETHYLAMINO)-2-PHENYL-2-BUTANOL
[CAS]

5612-61-3
[Synonyms]

1-(DIMETHYLAMINO)-2-PHENYL-2-BUTANOL
1-(Dimethylamino)-2-phenylbutan-2-ol
α-[(DiMethylaMino)Methyl]-α-ethyl-benzeneMethanol
α-[(Dimethylamino)methyl]-α-ethyl-benzenemethanol
Benzenemethanol, α-[(dimethylamino)methyl]-α-ethyl-
[Molecular Formula]

C12H19NO
[MDL Number]

MFCD12974676
[MOL File]

5612-61-3.mol
[Molecular Weight]

193.29
Chemical PropertiesBack Directory
[Boiling point ]

78-79 °C(Press: 1 Torr)
[density ]

0.9645 g/cm3
[solubility ]

DCM, Ethyl Amine
[form ]

Oil
[pka]

14.13±0.29(Predicted)
[color ]

Colorless
Hazard InformationBack Directory
[Uses]

α-[(Dimethylamino)methyl]-α-ethyl-benzenemethanol is an intermediate in the preparation of pharmaceutical goods.
[Synthesis]

1-(Dimethylamino)-2-phenylbutan-2-ol is primarily synthesised via a Strecker synthesis-based route. Strecker Synthesis-Based Route: This multi-step synthesis begins with the reaction of propiophenone, dimethylamine, and a cyanide source (like sodium cyanide) to form the α aminonitrile, 2-(N,N-dimethylamino)-2-phenylbutyronitrile.  This intermediate then undergoes hydrolysis to the corresponding carboxylic acid, followed by esterification and finally reduction of the ester to yield the target amino alcohol.
Synthesis of 1-(DIMETHYLAMINO)-2-PHENYL-2-BUTANOL
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