| Identification | Back Directory | [Name]
ACTH (4-9) | [CAS]
56236-83-0 | [Synonyms]
L-Tryptophan, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl- | [Molecular Formula]
C42H56N12O9S | [MDL Number]
MFCD00167481 | [MOL File]
56236-83-0.mol | [Molecular Weight]
905.03 |
| Hazard Information | Back Directory | [Uses]
ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH[1][2]. | [in vivo]
ACTH (4-9) (1 mg/kg; i.h.; pregnant females or newborn pups) suppresses related behavioral performance capability in later life[1]. | Animal Model: | Pregnant female mouse or newborn pups[1] | | Dosage: | 1 mg/kg | | Administration: | Subcutaneous injection | | Result: | Inhibited learning/memory task performance m males and females mouse. |
| [References]
[1] Honour LC, et, al. Pre- and postnatally administered ACTH, Organon 2766 and CRF facilitate or inhibit active avoidance task performance in young adult mice. Peptides. 1988 Jul-Aug;9(4):745-50. DOI:10.1016/0196-9781(88)90116-7
[2] Sekita-Krzak J, et, al. Protective effects of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: ultrastructural studies. Ann Univ Mariae Curie Sklodowska Med. 2002;57(2):233-8. PMID:12898845 |
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