| Identification | Back Directory | [Name]
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one | [CAS]
5627-05-4 | [Synonyms]
dihydrouridine
Uridine, 5,6-dihydro-
Uridine Impurity 28（5,6-Dihydrouridine）
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one | [Molecular Formula]
C9H14N2O6 | [MDL Number]
MFCD00047490 | [MOL File]
5627-05-4.mol | [Molecular Weight]
246.22 |
| Chemical Properties | Back Directory | [density ]
1.614±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml | [form ]
A crystalline solid | [pka]
12.40±0.20(Predicted) | [color ]
White to off-white | [PH]
～11 | [λmax]
208 (in H2O) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. | [Definition]
ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C |
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