| Identification | Back Directory | [Name]
Terbufibrol | [CAS]
56488-59-6 | [Synonyms]
K-11267
Terbufibrol
Reaxys ID: 2949416
p-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid
p-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acid
Benzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]- | [Molecular Formula]
C20H24O5 | [MDL Number]
MFCD00868432 | [MOL File]
56488-59-6.mol | [Molecular Weight]
344.4 |
| Chemical Properties | Back Directory | [Boiling point ]
439.5°C (rough estimate) | [density ]
1.1444 (rough estimate) | [refractive index ]
1.5400 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4.41±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Terbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat. | [in vivo]
Terbufibrol (20-200 mg/kg) is active in lowering serum TC in animals on all 3 diets, but the extent of cholesterol reduction varies in the order cholesterol (HC)>high protein and fat diet (HPF)>N (max. reductions: 154, 80, and 70%, respectively). Clofibrate (200 mg/kg) decreases TC by a maximum of 28% with the HPF-diet and 13% with the N-diet but is inactive with the HC-diet. Cholestyramine (400 mg/kg/day) is inactive in HPF-fed animals but reduces TC in HC-fed animals by 45%. With the HPF-diet nicotinic acid (200 mg/kg) is inactive. Terbufibrol lowers HDL, HDL-TC, LDL, LDL-TC and LDL-TC/PL in animals fed HPF-diet. A greater decrease of LDL-TC occurres with increasing dose. The main effect of Clofibrate (200 mg/kg) is to reduce HDL and HDL-TC and to increase LDL[1]. | [References]
[1] Howard AN, et al. The hypocholesterolemic effect of terbufibrol and other drugs in normal and hypercholesterolemic baboons. Atherosclerosis. 1979 Apr;32(4):367-80. DOI:10.1016/0021-9150(79)90004-2 |
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