| Identification | Back Directory | [Name]
Glutaurine | [CAS]
56488-60-9 | [Synonyms]
glutaurin
Litoralon
γ-Glu-Tau
Glutaurine
Sulfoglutamide
γ-Glutamyltaurine
L-γ-Glutamyltaurine
gamma-Glutamyltaurine
gamma-L-Glutamyltaurine
Nδ-(2-Sulfoethyl)-L-glutamine
L-Glutamine, N-(2-sulfoethyl)-
(2s)-2-amino-5-oxo-5-(2-sulfoethylamino)pentanoic Acid | [Molecular Formula]
C7H14N2O6S | [MDL Number]
MFCD01725191 | [MOL File]
56488-60-9.mol | [Molecular Weight]
254.26 |
| Chemical Properties | Back Directory | [Melting point ]
223-226 °C | [density ]
1.520±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMF: insol; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): 5 mg/ml | [form ]
A solid | [pka]
1.40±0.50(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : 125 mg/mL (491.62 mM; Need ultrasonic) |
| Hazard Information | Back Directory | [Uses]
Glutaurine has been observed to display antiepileptic effects with anti-amnesia properties. Mimics anxiolytic drug Diazepam (D416855). | [Definition]
ChEBI: Glutaurine is a dipeptide resulting from the formal condensation of the amino group of taurine with the gamma-carboxy group of L-glutamic acid. It was initially found in the parathyroid in 1980 and later in the brain of mammals. It has a role as a mouse metabolite, a mammalian metabolite, a human metabolite, an anticonvulsant, an anxiolytic drug and a hormone. It is a L-glutamine derivative, a sulfonic acid and a dipeptide. It is functionally related to a taurine. It is a tautomer of a glutaurine zwitterion. | [in vivo]
Glutaurine (1, 10, 20 or 50 μg/rat; p.o.) significantly restores the latency of entry in both the 24 and 48 hours tests at the dose of 50 μg/rat[2].
Glutaurine (100~3000 ug/kg; i.p.) significantly reduces T3 blood levels in a dose-dependent manner, but does not significantly raise T4 blood levels[3]. | Animal Model: | CFY male rats (170~250g)[2] | | Dosage: | 1, 10, 20 or 50 μg/rat | | Administration: | P.o. | | Result: | Significantly restored the latency of entry in both the 24 and 48 h tests at the dose of 50 μg/rat.
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| Animal Model: | Fischer 344 rats[3] | | Dosage: | 100~3000 ug/kg | | Administration: | I.p. | | Result: | Significantly reduced T3 blood levels in a dose-dependent manner, but did not significantly raise T4 blood levels.
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