| Identification | Back Directory | [Name]
Brodimoprim | [CAS]
56518-41-3 | [Synonyms]
HypriM
UnitriM
Ro-10-5970
brodimoprim
Bromidoprim
Bromodiprim
bromdimoprim
Hyprim：Unitrim
Brodimoprim USP/EP/BP
Benzenesulfonicacid,8-(bromomethyl)-
5-(4-BroMo-3,5-diMethoxybenzyl)-2,4-pyriMidinediaMine
5-(3,5-Dimethoxy-4-bromobenzyl)-2,4-pyrimidinediamine
5-(4-Bromo-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine
5-(3,5-dimethoxy-4-bromobenzyl)-2,4-diaminopyrimidine
5-((4-bromo-3,5-dimethoxyphenyl)methyl)-4-pyrimidinediamine
5-((4-bromo-3,5-dimethoxyphenyl)methyl)-2,4-pyrimidinediamine
2,4-Pyrimidinediamine, 5-[(4-bromo-3,5-dimethoxyphenyl)methyl]- | [EINECS(EC#)]
260-238-8 | [Molecular Formula]
C13H15BrN4O2 | [MDL Number]
MFCD00864849 | [MOL File]
56518-41-3.mol | [Molecular Weight]
339.188 |
| Chemical Properties | Back Directory | [Melting point ]
225-228° | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Sparingly) | [form ]
Solid | [pka]
7.15(at 25℃) | [color ]
White to Pale Yellow | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
Brodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of
common infections of upper respiratory tract such as sinusitis and exacerbation of chronic
bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and
-negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely
used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic
profile exemplified by its long half-life and good tissue penetration. | [Chemical Properties]
Off-White to Pale Yellow Solid | [Originator]
Helsinn (Switzerland) | [Uses]
A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. | [Definition]
ChEBI: An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group. | [Brand name]
Hyprim;Unitrim |
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