56523-59-2

4617-33-8

56523-59-2

General procedure for the synthesis of 15-bromopentadecanoic acid from 15-hydroxypentadecanoic acid: 177 g (0.69 mol) of 15-hydroxypentadecanoic acid prepared in step (1) was placed in a reaction vessel and 577.4 g (3.43 mol) of 48% hydrobromic acid/acetic acid solution was added. At room temperature, 240 ml of concentrated sulfuric acid was slowly added, followed by heating and refluxing the reaction mixture for 6 hours. After completion of the reaction, it was cooled to room temperature and the organic layer was separated by extraction with dichloromethane. The organic layer was sequentially washed with water, dried over anhydrous magnesium sulfate (MgSO4) and finally concentrated under vacuum. 195 g of white 15-bromopentadecanoic acid powder was obtained in 88% yield.