| Hazard Information | Back Directory | [Uses]
Antibacterial. | [in vivo]
Trimethoprim (10 mg/kg; i.v.; once every 12 h; 3 d) shows antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis in infected mice[2].
Trimethoprim can be connected with the thiomaltose (TM-TMP) and shows stability with a half-life of about 1 hour in complete serum, and has an MIC value around 1 μM against E. coli[2].
Trimethoprim (10 mg/mL; 0.5 mL; inject with Trimethoprim-Zn combined suspension) decreases the virus titer and increases the survival rate of chicken embryo[4]. | Animal Model: | Female C3H/HeOuJ mice (transurethrally infected with a 50 μL suspension containing 1-2×107 CFU of E. coli under 3% isoflurane)[2] | | Dosage: | 10 mg/kg | | Administration: | i.v.; once every 12 h; for 3 d | | Result: | Showed antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis with CD50s of 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively in infected mice. |
| Animal Model: | Fertilized eggs (injected H3N2 virus into amniotic and allantoic space at day 8)[4] | | Dosage: | 10 mg/mL; 0.5 mL | | Administration: | The Trimethoprim-Zn combined suspension was injected into the air sac; single dosage | | Result: | Decreased the virus titer and increased the survival rate of chicken embryo.
The survival rate peaked at ratio about 0.18 (Zn/Trimethoprim). |
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