ChemicalBook--->CAS DataBase List--->56632-39-4

56632-39-4

56632-39-4 Structure

56632-39-4 Structure
IdentificationBack Directory
[Name]

BHPI
[CAS]

56632-39-4
[Synonyms]

BHPI
CS-2134
1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
[Molecular Formula]

C21H17NO3
[MOL File]

56632-39-4.mol
[Molecular Weight]

331.36
Chemical PropertiesBack Directory
[Melting point ]

272-274 °C
[Boiling point ]

557.7±50.0 °C(Predicted)
[density ]

1.320±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMF: 5 mg/ml; DMSO: 11 mg/ml; Ethanol: 14 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
[form ]

A crystalline solid
[pka]

9.43±0.30(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily. BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.
[Uses]

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial and ovarian cancer cell lines.
[in vivo]

BHPI (10-15 mg/kg; i.p.; daily, 10 days or every other day, until the end of the experiment) inhibits tumor growth and results in rapid regression of 48/52 tumors in a mouse xenograft model using MCF-7 tumors[1].

[storage]

Store at -20°C
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