| Identification | Back Directory | [Name]
3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE | [CAS]
567-01-1 | [Synonyms]
5-A-pregnane-3-B-21-diol-20-one
3β,5α-Tetrahydrodeoxycorticosterone
"3β,5a-Tetrahydrodeoxycorticosterone"
5-ALPHA-PREGNAN-3-BETA, 21-DIOL-20-ONE
3-beta,5-alfa-Tetrahydrodeoxycorticosterone
3-BETA,5-ALPHA-TETRAHYDRODEOSOXYCORTICOSTERONE
1-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-7-hydroxy-9
a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]p
henanthren-1-yl]-2-hydroxyethan-1-one | [Molecular Formula]
C21H34O3 | [MDL Number]
MFCD00069492 | [MOL File]
567-01-1.mol | [Molecular Weight]
334.49 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤25mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide | [form ]
crystalline solid |
| Hazard Information | Back Directory | [Description]
3β,5α-THDOC is a neurosteroid. It inhibits seizures induced by pilocarpine, but not pentylenetetrazol (PTZ; ), in mice (ED50s = 45.9 and >100 mg/kg, respectively). 3β,5α-THDOC has been found in the urine of women during the third trimester of pregnancy. | [Uses]
3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown
that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons. | [Uses]
3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons. | [in vitro]
epiallopregnanolone showed no effects on the gaba-mediated chloride flux through several types of recombinant gaba receptors. epiallopregnanolone inhibited the allopregnanolone-stimulated gaba-mediated chloride flux through gabaa receptors. epiallopregnanolone antagonized the inhibitory effects of allopregnanolone and ethanol on the population spike in the ca1 region of the hippocampal brain slices [1]. epiallopregnanolone selectively blocked the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[3]. | [in vivo]
in rats trained to discriminate either 0.8g/kg or 1.2 g/kg ethanol, 100 mg/kg epiallopregnanolone treatment decreased the maximum effect by 40% and 54% ethanol lever, respectively. epiallopregnanolone significantly decreased response rates when compared with control condition [1]. | [References]
[1] ginsburg b c, lamb r j. alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol[j]. alcoholism: clinical and experimental research, 2005, 29(9): 1621-1629.
[2] macdonald r l, olsen r w. gabaa receptor channels[j]. annual review of neuroscience, 1994, 17(1): 569-602.
[3] wang m, bckstrm t, landgren s. epiallopregnanolone selectively blocks the allopregnanolone inhibition of the population spike in the rat hippocampal ca1[j]. acta physiologica scandinavica, 1999, 167(2): a5-a5. |
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