| Identification | Back Directory | [Name]
Benzoic acid, 2-amino-6-hydroxy- | [CAS]
567-62-4 | [Synonyms]
6-Aminosalicylic acid
Mesalazine Impurity 24
Mesalazine Impurity 22
6-Hydroxyanthranilic acid
2-Amino-6-hydroxybenzoic acid
Benzoic acid, 2-amino-6-hydroxy-
Benzoic acid, 2-amino-6-hydroxy- ISO 9001：2015 REACH | [Molecular Formula]
C7H7NO3 | [MDL Number]
MFCD16999405 | [MOL File]
567-62-4.mol | [Molecular Weight]
153.14 |
| Chemical Properties | Back Directory | [Melting point ]
148℃ | [Boiling point ]
352.2±32.0 °C(Predicted) | [density ]
1.491 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.30±0.25(Predicted) | [color ]
Light Brown to Brown |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 6-hydroxy-o-toluic acid from 2-amino-6-methoxybenzoic acid: boron tribromide (1 M in dichloromethane, 3 eq.) was slowly added dropwise to an anhydrous dichloromethane solution of 2-amino-6-methoxybenzoic acid (1 eq.) at -78 °C (dry ice/acetone bath). The reaction mixture was stirred at room temperature and under nitrogen protection for 18 hours. Upon completion of the reaction, the reaction was quenched by the addition of ethanol and methanol, followed by evaporation to remove the solvent to give a brown solid product. The product can be used in subsequent reactions without further purification. The product was a brown solid in 75% yield. | [References]
[1] European Journal of Medicinal Chemistry, 2014, vol. 76, p. 343 - 351
[2] Journal of Organic Chemistry, 1991, vol. 56, # 23, p. 6666 - 6671 |
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