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Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis[1]. | [Definition]
ChEBI: Luteolin 7-sulfate is a member of flavones. | [References]
[1] Lee SW, et al. Luteolin?7-Sulfate?Attenuates Melanin Synthesis through Inhibition of CREB- and MITF-Mediated Tyrosinase Expression. Antioxidants (Basel).?2019 Apr 4;8(4). DOI:10.3390/antiox8040087 |
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