56893-25-5

3609-53-8

56893-25-5

General procedure for the synthesis of methyl 4-(2-bromoacetyl)benzoate from methyl 4-acetylbenzoate: Bromine (2.71 mL, 52.5 mmol) was added dropwise to a solution of methyl 4-acetylbenzoate (8.91 g, 50.0 mmol) in acetic acid (80 mL). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and filtered to collect the solid. The resulting precipitate was washed with a 1:1 mixed methanol-water solution and subsequently dried to afford methyl 4-(2-bromoacetyl)benzoate (10.6 g, 82% yield) as a brown solid. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of δ 8.19-8.12 (m, 2H), 8.04 (d, J = 8.5 Hz, 2H), 4.47 (s, 2H), 3.96 (s, 3H).