| Identification | Back Directory | [Name]
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID | [CAS]
569371-10-4 | [Synonyms]
UBP 301
(aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoicacid
(αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoicacid
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
(alphaS)-alpha-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid | [Molecular Formula]
C15H14IN3O6 | [MDL Number]
MFCD06411591 | [MOL File]
569371-10-4.mol | [Molecular Weight]
459.19 |
| Chemical Properties | Back Directory | [Melting point ]
214.1-214.4 °C(Solv: water (7732-18-5)) | [Boiling point ]
636.1±65.0 °C(Predicted) | [density ]
1.98±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: 0.5 mg/ml (w/ gentle warming) | [form ]
A crystalline solid | [pka]
2.12±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
UBP 301 is an antagonist of the kainate receptor, an ionotropic glutamate receptor (apparent Kd = 5.94 μM). It displays ~30-fold selectivity over AMPA receptors. UBP 301 is used to assess the roles of kainate receptors in neuronal signaling, particularly in reference to neuropathic pain. | [Uses]
UBP 301 is an antagonist of kainate receptors. UBP 301 is the N3-4-carboxybenzyl substituted analog II of Willardiine, which was found to be equipotent at AMPA and GLUK5-containing kainate receptors in the neonatal rat spinal cord. | [Biological Activity]
Potent kainate receptor antagonist (apparent K d = 5.94 mM). Displays ~ 30-fold selectivity over AMPA receptors. | [storage]
Store at +4°C | [References]
[1] JULIA C A MORE. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists[J]. British Journal of Pharmacology, 2009, 138 6: 1093-1100. DOI: 10.1038/sj.bjp.0705148
[2] SUZANNE DOOLEN. Peripheral nerve injury increases glutamate-evoked calcium mobilization in adult spinal cord neurons.[J]. Molecular Pain, 2012, 8: 56. DOI: 10.1186/1744-8069-8-56
[3] DOREEN B OSGOOD. The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats.[J]. Surgical Neurology International, 2013, 4: 106. DOI: 10.4103/2152-7806.116791 |
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