| Identification | Back Directory | [Name]
1H-3-Benzazepin-2-amine, 7,8-dimethoxy- | [CAS]
57184-68-6 | [Synonyms]
LY-127210 free base
LY127210 free base,LY 127210 free base
1H-3-Benzazepin-2-amine, 7,8-dimethoxy- | [Molecular Formula]
C12H14N2O2 | [MDL Number]
MFCD18800919 | [MOL File]
57184-68-6.mol | [Molecular Weight]
218.25 |
| Hazard Information | Back Directory | [Uses]
LY127210 (free base) is a potent vasodilator with antihypertensive effects that reduces pressure in chloralose-anesthetized spontaneously hypertensive rats primarily by direct arteriolar dilation and to a lesser extent by decreasing cardiac output. LY127210 (free base) reduces blood pressure, heart rate and left ventricular end-diastolic pressure in hypertensive rats by reducing vascular resistance[1]. | [References]
[1] Steinberg MI, et al. Hemodynamic and vascular activity of LY127210, a new vasodilator, in anesthetized spontaneously hypertensive rats: comparison with hydralazine. Clin Exp Hypertens A. 1985;7(10):1481-97. DOI:10.3109/10641968509073605 |
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