| Identification | Back Directory | [Name]
DITION | [CAS]
572-48-5 | [Synonyms]
DITION
Thiophosphoric acid O,O-diethyl O-(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl) ester
Phosphorothioic acid, O,O-diethyl O-(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyran-3-yl) ester
coumithoate (ISO) O,O-diethyl O-7,8,9,10-tetrahydro-6-oxo-benzo(c)chromen-3-yl phosphorothioate | [Molecular Formula]
C17H21O5PS | [MOL File]
572-48-5.mol | [Molecular Weight]
368.38 |
| Hazard Information | Back Directory | [Uses]
Insecticide. | [Description]
Coumithoate is an obsolete organophosphate insecticide. The substance has not been extensively studied and so little information is known regarding its environmental fate, ecotoxicity or impact on human health. | [Production Methods]
Coumithoate was manufactured using the same multipurpose plant chemistry applied to other thio phosphate esters. Commercial production began with preparation of the O alkyl phosphorochloridothioate intermediate, typically generated by reacting phosphorus oxychloride or phosphorus thiochloride with the required alcohol under strictly anhydrous, acid scavenged conditions. In a separate step, the N methylcarbamate derived heterocycle (the coumarin based moiety characteristic of coumithoate) was synthesised and purified. The two components were then coupled in a controlled esterification step, usually in aromatic or chlorinated solvents, with careful temperature management to control hydrogen chloride evolution. After reaction completion, the crude mixture underwent aqueous neutralisation, phase separation, solvent exchange, and vacuum stripping, yielding technical grade coumithoate. | [Mechanism of action]
Acetylcholinesterase (AchE) inhibitor. | [Pesticide Type]
Insecticide; Acaricide; Miticide |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P264-P270-P301+P310-P321-P330-P405-P501 | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
28-36/37-45 | [RIDADR ]
2783 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Poison by ingestion.
When heated to decomposition it emits very
toxic fumes of POx and SOx. See also
PARATHION. | [Toxicity]
LD50 orally in rats: 67 mg/kg (Ben-Dyke) |
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