| Identification | Back Directory | [Name]
METHOXYRESORUFIN | [CAS]
5725-89-3 | [Synonyms]
METHOXYRESORUFIN
O-Methylresorufin
O7-Methylresorufin
7-methoxyresorufin
O7-METHYLRESORUFINE
7-Methoxyphenoxazone
RESORUFIN METHYL ETHER
7-methoxyphenoxazin-3-one
RESORUFIN 7-O-METHYL ETHER
7-METHOXY-3H-PHENOXAZIN-3-ONE
3H-Phenoxazin-3-one, 7-methoxy-
Resorufin methyl ether *CAS 5725-89-3*
O(7)-METHYLRESORUFINE, FOR FLUOR-ESCENCE
METHOXYRESORUFIN [RESORUFIN METHYL ETHER]
7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O7-Methylresorufin
Resorufin methyl ether,7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O7-Methylresorufin | [Molecular Formula]
C13H9NO3 | [MDL Number]
MFCD00037663 | [MOL File]
5725-89-3.mol | [Molecular Weight]
227.22 |
| Chemical Properties | Back Directory | [Melting point ]
≥220 °C(lit.)
| [Boiling point ]
378.8±42.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: soluble
| [form ]
Powder | [pka]
1.42±0.20(Predicted) | [color ]
Brown to reddish brown | [Appearance]
Solid Powder | [BRN ]
209529 | [InChI]
1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3 | [InChIKey]
KNYYMGDYROYBRE-UHFFFAOYSA-N | [SMILES]
COc1ccc2N=C3C=CC(=O)C=C3Oc2c1 |
| Hazard Information | Back Directory | [Description]
Methoxyresorufin is a fluorogenic substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Methyoxyresorufin is O-demethylated by CYP1A1/2, releasing resorufin, which displays excitation/emission maxima of 570/580 nm, respectively. The appearance of resorufin fluorescence can be used to quantify CYP1A1/2 activity. | [Uses]
Substrate for Cytochrome P-450. METHOXYRESORUFIN is used for various investigations including the differentiatiation of cytochrome P-450 isozymes.
| [Biochem/physiol Actions]
Fluorimetric substrate for cytochrome P450 linked enzymes. | [IC 50]
CYP1 | [storage]
Store at -20°C | [References]
[1] RICHARD T. MAYER . Methoxyresorufin as a substrate for the fluorometric assay of insect microsomal O-dealkylases[J]. Pesticide Biochemistry and Physiology, 1977, 7 4: Pages 349-354. DOI: 10.1016/0048-3575(77)90038-4
[2] PRATIBHA V. NERURKAR . Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 AND 2B, respectively, in the rat and mouse[J]. Biochemical pharmacology, 1993, 46 5: Pages 933-943. DOI: 10.1016/0006-2952(93)90504-p
[3] M.V. CABALLERO . Fipronil induces CYP isoforms in rats[J]. Food and Chemical Toxicology, 2015, 83: Pages 215-221. DOI: 10.1016/j.fct.2015.06.019
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. | [Excitation / Emission Maximum]
571 nm/585 nm |
|
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