| Identification | Back Directory | [Name]
7-BROMO-4-CHLOROQUINAZOLINE | [CAS]
573675-55-5 | [Synonyms]
7-Bromo-4-chloro-quizoline
7-BROMO-4-CHLOROQUINAZOLINE
7-BroMo-4-chloroquinazoli...
Quinazoline, 7-bromo-4-chloro- | [Molecular Formula]
C8H4BrClN2 | [MDL Number]
MFCD06657216 | [MOL File]
573675-55-5.mol | [Molecular Weight]
243.488 |
| Chemical Properties | Back Directory | [Boiling point ]
339.7±22.0 °C(Predicted) | [density ]
1.762±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
0.09±0.30(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 7-bromo-4-chloroquinazoline from 7-bromo-3,4-dihydroquinazolin-4-one: 20.4 mL (0.12 mol) of N-ethyl diisopropylamine was added slowly and dropwise to 55.0 g (0.24 mol) of 7-bromo-3H-quinazolin-4-one suspended in 300 mL of phosphorus trichloride. The reaction mixture was stirred at 115 °C for 3 hours and subsequently cooled to room temperature. After conventional post-processing, 48.0 g of the target product 7-bromo-4-chloroquinazoline was obtained as a solid as confirmed by HPLC/MS analysis ([M+H]+ = 244). | [References]
[1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0183
[2] Patent: WO2010/146173, 2010, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2005/42498, 2005, A2. Location in patent: Page/Page column 43
[4] Chemical Biology and Drug Design, 2018, vol. 92, # 5, p. 1859 - 1866 |
|
|