| Identification | Back Directory | [Name]
ketohypoglycin | [CAS]
5746-24-7 | [Synonyms]
ketohypoglycin
Methylenecyclopropylpyruvate
Cyclopropanepropanoic acid, 2-methylene-α-oxo- | [Molecular Formula]
C7H8O3 | [MOL File]
5746-24-7.mol | [Molecular Weight]
140.14 |
| Hazard Information | Back Directory | [Description]
Ketohypoglycin has been used to study the inhibition of gluconeogenesis in isolated rat liver cells. | [Uses]
Methylenecyclopropylpyruvate (Ketohypoglycin) is an inhibitor for gluconeogenesis. Methylenecyclopropylpyruvate inhibits ketogenesis and affects the fatty acids metabolism. Methylenecyclopropylpyruvate may interfere with the mitochondrial β-oxidation pathway, affects the contents and composition of coenzyme A, and affects the glucose homeostasis[1]. | [Definition]
ChEBI: Beta-(methylenecyclopropyl)pyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens has been replaced by a methylenecyclopropyl group. It has a role as a rat metabolite and a xenobiotic metabolite. It is a 2-oxo monocarboxylic acid, a member of cyclopropanes and an olefinic compound. It is functionally related to a pyruvic acid. | [References]
[1] Kean EA, et al., Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin). Biochem J. 1979 Sep 15;182(3):789-96. DOI:10.1042/bj1820789 |
|
|